Cisplatin hearing loss thesis

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August undefined, 2024

WebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy … WebAug 25, 2024 · Platinum containing chemotherapeutic agents are associated with cochleotoxicity, characterized by high frequency hearing loss. Cisplatin and related …

Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity

WebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and … WebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the … iphone fk

Ototoxicity in patients receiving concurrent cisplatin …

WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients. WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... http://etds.lib.ncku.edu.tw/etdservice/detail?n=20&etdun3=U0026-0808201316053000&etdun4=U0026-2308201215132500&etdun7=U0026-2607201113092800&etdun9=U0026-0108201016204100&etdun10=U0026-2706201001360500&etdun11=U0026-2601201019334400&etdun12=U0026-2408201016131400&etdun18=U0026-0812200911435655&etdun19=U0026-0812200911293383&etdun20=U0026-0812200911134013 iphonefixuk trustpilot

Hearing Loss: An Under-Recognized Side Effect of Cancer Treatment

Mechanisms of Cisplatin Ototoxicity and Routes for Intervention

WebJan 26, 2024 · A New Approach to Researching Cisplatin-Induced Hearing Loss. The new study differs from previous research because it is a comprehensive look at the pharmacokinetics, or concentration, of the … WebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … iphone fix rochester mnWebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological iphone fix store near me bloomington

"WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Prevention and Restoration of Hearing Loss Associated …

WebThis thesis is based on the following original papers, which will be referred to in the text by their Roman numerals I-V. Ekborn A, Laurell G, Andersson A, Wallin I, Eksborg S, Ehrsson H. Cisplatin-induced hearing loss: influence of the mode of drug administration in the guinea pig. Hear Res 2000;140(1-2):38-44. WebApr 17, 2024 · For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. Reported rates of cisplatin …

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WebImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late … WebFeb 12, 2024 · More information: Diana J Moke et al. Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study ...

WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. Cisplatin and similar platinum-based drugs are prescribed for an estimated 10 to 20 percent of all cancer patients.

WebApr 26, 2024 · 1 In a recent study, most patients (388 of 488, 80%) had a hearing loss of at least 20 dB and 40% suffered from tinnitus. 2 Sixty-three to 77% of children 3 4 suffer permanent sensorineural hearing loss from cisplatin chemotherapy. Cisplatin primarily affects the high frequencies in both ears and is permanent. Web20 hours ago · The drug, which is Fennec's sole product, is intended to prevent hearing loss in pediatric cancer patients treated with cisplatin chemotherapy.

WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …

WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. iphone fixppo downloadWebHigh-dose cisplatin treatment: hearing loss and plasma concentrations. Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) … iphone flashes apple logoWebCisplatin-Induced Hearing Loss Childhood Cancer Hearing Loss Patient Focused Drug Development (PFDD) Meeting The pediatric patient population with chemotherapy … iphonefixuk couponWebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss. iphone flashes when textWebCisplatin may cause serious hearing problems, especially in children. Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking ... iphone flagshipWebDec 18, 2024 · December 18, 2024. Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear. iphone flagship phoneWebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … iphone flashing the apple logo