Ctgf and liver fibrosis

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August undefined, 2024

WebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is … WebSep 16, 2012 · CTGF is overexpressed in human liver fibrosis/cirrhosis of various aetiologies and in experimental liver fibrogenesis [ 12 - 16 ]. It is a major fibrogenic signal, with TGF-β-dependent activity when produced in hepatocytes, and TGF-β-independent activity when derived from HSCs [ 17 ].

Cells Free Full-Text The Role of CTGF in Liver Fibrosis Induced i…

WebAug 6, 2024 · Background: Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can … WebJan 12, 2011 · In patients with IPF, CTGF levels are elevated in transbronchial biopsy specimens and in bronchoalveolar lavage fluid. Increased levels of CTGF have also been observed in experimental models of lung fibrosis. In addition, CTGF can cause susceptibility to experimentally-induced lung fibrosis in otherwise resistant mice. list of psp in kenya

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

WebMay 28, 2024 · CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis. CTGF was found to be overexpressed in fibrotic lesions in major organs, including the lung, kidney, liver, skin, cardiovascular system, gastrointestinal system, eye, and gingiva [8]. WebMay 2, 2006 · Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to … WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, and alcoholic or nonalcoholic hepatic steatosis [].Although the pathogenesis of hepatic fibrosis is not revealed clearly, hepatic stellate cells (HSCs) are believed to be a major role in the … imind health llc

Hepatic stellate cells as key target in liver fibrosis - PMC

Connective tissue growth factor (CTGF/CCN2) in hepatic …

Web氯雷他定是一种h1受体阻滞剂，具有抗炎、抗过敏、抗氧化等药理作用。有研究结果表明，氯雷他定对于急性肝损伤有保护作用 [] ，但评估氯雷他定对于慢性肝损伤造成的肝纤维化的影响报道尚少。本研究利用脂多糖制备大鼠肝纤维化模型，探究氯雷他定对大鼠肝纤维化的作用及其机制。 WebMar 22, 2024 · The levels of hepatocyte-derived CTGF are usually low, and elevated levels of hepatic CTGF have been observed in patients with liver fibrosis and in experimental animal models of liver fibrosis ... list of psoriatic arthritis medicinesWebLong-term injury to liver cells and consistent activation of the fibrogenic response can lead to liver fibrosis such as that seen in chronic alcoholics or clinically obese individuals. … imind clothing

"WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF … " - Ctgf and liver fibrosis

Ctgf and liver fibrosis

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WebAug 22, 2024 · Accordingly, hepatic fibrosis occurs when liver is repeatedly and continuously injured. Damage to hepatocytes triggers the release of reactive oxygen species (ROS) and inflammatory mediators, which would stimulate carcinogenic process . Untreated fibrosis may progress to liver cirrhosis, leading to organ failure and hepatoma [3,4]. … WebAug 28, 2024 · A similar effect of sol-Eng on secreted CTGF in the supernatant is seen at higher ligand concentrations. ... the noncoding RNA-H19 enhance transdifferentiation of cultured mouse primary HSC and promote progression of cholestatic liver fibrosis . …

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WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF gene promoter methylation WebFeb 16, 2024 · Connective tissue growth factor (CTGF) expression in hepatic stellate cells (HSCs) and liver endothelial cells correlates with the extent of acute liver injury, and …

WebIn fibrotic liver, CTGF/CCN2 mRNA and protein are produced by fibroblasts, myofibroblasts, hepatic stellate cells (HSCs), endothelial cells, and bile duct … WebDec 5, 2024 · Liver fibrosis was induced through IP injection of CCl 4 (0.5 µl/g body weight) twice a week for six weeks the Ccn2/Ctgf conditional mouse knockouts. The hepatocyte-specific Ccn2/Ctgf knockouts (KO) in …

WebApr 8, 2024 · Multiple studies illustrate the abilities of neutralizing anti-TGF-β antibodies and TGF-β receptor kinase inhibitors to prevent fibrosis in preclinical models of lung, liver, … WebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), cholestatic liver disease, and autoimmune hepatitis. ... resulting in the inhibition of CTGF and its downstream targets .

WebFeb 7, 2012 · Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). …

WebApr 11, 2024 · various inﬂammatory modulators, including TGF-β and CTGF, in a paracrine manner has been reported. In addition to ... Liver fibrosis is a common pathological process of chronic liver diseases ... list of psu in keralaWebJun 13, 2024 · Connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN family of matricellular proteins, is widely known as a hallmark of fibrosis in multiple tissues, including skin, heart, lung, liver, and kidney [ 3, 4 ]. list of psp shooting gamesWebJan 21, 2024 · CTGF is a kind of matrix protein that is commonly up-regulated in the liver fibrosis, which plays a key role in liver fibrosis (Weiskirchen, 2016; Wu et al., 2024b; Makino et al., 2024). Studies have shown that hepatocytes, bile duct cells, HSCs and many other cells express and secrete CTGF protein in the fibrotic liver ( Williams et al., 2014 ... imind lifeWebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver … list of psu companies in maharashtraWebSep 21, 2024 · It has been reported that the levels of TGF-β 1 on patients with null-mild liver fibrosis are higher than those with advanced liver fibrosis, which hint that TGF-β 1 may … list of pssm positive stallionsWebDec 5, 2024 · These observations demonstrate conserved cross-species functions of Ccn2/Ctgf protein in rodent livers. This protein can be induced in hepatocytes and … list of psp rpg gamesWebDec 3, 2024 · Liver fibrosis is a multicellular response to liver injury in which hepatic stellate cells (HSCs) are responsible for 90% of extracellular matrix (ECM) production … list of psu in bihar