Topical diphenyl diselenide mice research
WebAbstract. In the current study, nanocapsules (NC) formulations containing a co-load of clotrimazole (C), a highly prescribed antifungal drug, and diphenyl diselenide [(PhSe) 2], an organoselenium compound with a promising scope of pharmacological actions, were prepared.Formulations were characterized as well as the potential toxicity, antioxidant … WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, oxidative stress and reduction ...
Topical diphenyl diselenide mice research
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WebJan 1, 2024 · The current study investigated the effect of organoselenium compound p,p′-methoxyl-diphenyl diselenide [(OMePhSe) 2], free or incorporated into nanocapsules, on behavioral, biochemical and molecular alterations in an inflammatory pain model induced by complete Freund's adjuvant (CFA). Male Swiss mice received an intraplantar injection of … WebThe present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe) 2 and diphenyl ditelluride (PhTe) 2 in mice after in vivo administration. …
WebJan 20, 2024 · It was observed that diphenyl diselenide was less toxic in rats than in mice—the LD 50 of this compound was 374.4 mg/kg in rats and 65.52 mg/kg in mice after … WebAug 25, 2024 · Diphenyl diselenide was effective against 32 Aspergillus isolates (MIC 64 µg mL −1 ), which increased the fungicidal action of the drug caspofungin, but was ineffective against an aspergillosis ...
WebOct 24, 2024 · Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an … WebMice were pretreated with Se-PTC (1–50 mg/kg), via the peroral route (p.o), 0.5 h before injection with acetate. Control animals received a similar volume of the vehicle (10 ml/kg, canola oil) as the negative, or Celecoxib(150 mg/kg,p.o.)asthepositivecontrol.Post-challenge,the mice were placed individually into separate boxes and the total
WebSep 1, 2010 · The results suggest that (PhSe)2 may be useful for the treatment of cognitive impairment that may hold significant therapeutic value in alleviating certain memory deficits observed in Alzheimer's disease. This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by …
WebDiphenyl diselenide (Ph 2 Se 2) is an organoselenium compound.Its crystalline structure,[] toxicokinetic properties,[] antioxidant and anti-inflammatory activities have been investigated.[] Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice.[] It reacts with thallium … first round of puppy shots costWebBisphenol A (BPA) is a chemical toxicant that has deleterious effects on human. BPA causes oxidative stress in tissues, including the liver. Diphenyl diselenide (PhSe) 2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells. In the … first round of nfl playoffs 2023WebDiphenyl diselenide is used in the methoxyselenenylation of alkenes, dihydroxylation of double bonds, hydrothiolation of terminal alkynes. It is used in the synthesis of the … first round of teaWebOct 28, 2010 · Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there … first round of testsWeboxyl-diphenyl diselenide, (p-Cl-C H Se) – p-chloro-diphenyl dise-lenide, (PhSe) – diphenyl diselenide, PTZ – pentylenetetra zole) Introduction Among the different neurological disorders that affect the human condition, epilepsy has been largely stud-ied during the last century [16, 27] and has become a dynamic research field in recent ... first round pick fantasy footballWebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 μmol/kg of diphenyl diselenide. At lower doses (25–150 μmol/kg), no seizures were observed. The LD 50 calculated and the 95% confident interval was 210 μmol/kg … first round pick nfl 2022WebDec 25, 2024 · Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) is a … first round of shots for puppies